PittsburghV1, Canada, Analysis, bibRecord, 000395

Sex Differences in Presentation and Outcome Among Patients With Type 2 Diabetes and Coronary Artery Disease Treated With Contemporary Medical Therapy With or Without Prompt Revascularization: A Report From the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes)

Identifieur interne : 000395 ( Canada/Analysis ); précédent : 000394; suivant : 000396

Sex Differences in Presentation and Outcome Among Patients With Type 2 Diabetes and Coronary Artery Disease Treated With Contemporary Medical Therapy With or Without Prompt Revascularization: A Report From the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes)

Auteurs : Jacqueline E. Tamis-Holland [États-Unis] ; JIANG LU [États-Unis] ; Mary Korytkowski [États-Unis] ; Michelle Magee [États-Unis] ; William J. Rogers [États-Unis] ; Neuza Lopes [Brésil] ; Lisa Mighton [Canada] ; Alice K. Jacobs [États-Unis]

Source :

Journal of the American College of Cardiology [ 0735-1097 ] ; 2013.

RBID : Pascal:13-0179523

Descripteurs français

Pascal (Inist)
- Diabète de type 2, Cardiopathie coronaire, Pathologie de l'appareil circulatoire, Sexe, Mâle, Femelle, Etude comparative, Homme, Pronostic, Evolution, Malade, Médecine, Revascularisation, Essai clinique, Dérivation, Angioplastie, Dilatation instrumentale, Appareil circulatoire, Cardiologie, Traitement instrumental.
Wicri :
- topic : Homme, Médecine.

English descriptors

KwdEn :
- Angioplasty, Bypass, Cardiology, Cardiovascular disease, Circulatory system, Clinical trial, Comparative study, Coronary heart disease, Evolution, Female, Human, Instrumental dilatation, Instrumentation therapy, Male, Medicine, Patient, Prognosis, Revascularization, Sex, Type 2 diabetes.

Abstract

Objectives This study evaluated differences in outcome among women and men enrolled in the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Background Women and men with coronary artery disease have different clinical presentations and outcomes that might be due to differences in management. Methods We compared baseline variables, study interventions, and outcomes between women and men enrolled in the BARI 2D trial and randomized to aggressive medical therapy alone or aggressive medical therapy with prompt revascularization. Results At enrollment, women were more likely than men to have angina (67% vs. 58%, p < 0.01) despite less disease on angiography (Myocardial Jeopardy Index 41 ± 24 vs. 46 ± 24, p < 0.01; number of significant lesions 2.3 ± 1.7 vs. 2.8 ± 1.8, p < 0.01). Over 5 years, no sex differences were observed in BARI 2D study outcomes after adjustment for difference in baseline variables (death/myocardial infarction/cerebrovascular accident: hazard ratio: 1.11, 99% confidence interval [CI]: 0.85 to 1.44). However, women reported more angina than men (adjusted odds ratio: 1.51, 99% CI: 1.21 to 1.89, p < 0.0001) and had lower scores for the Duke Activity Status Index (adjusted beta coefficient: -1.58, 99% CI: -2.84 to -0.32, p < 0.01). Conclusions There were no sex differences in death, myocardial infarction, or cerebrovascular accident among patients enrolled in the BARI 2D trial. However, compared with men, women had more symptoms and less anatomic disease at baseline, with persistence of higher angina rates and lower DASI scores after 5 years of medical therapy with or without prompt revascularization. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes [BAR1 2D]; NCT00006305).

Affiliations:

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Pascal:13-0179523

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Sex Differences in Presentation and Outcome Among Patients With Type 2 Diabetes and Coronary Artery Disease Treated With Contemporary Medical Therapy With or Without Prompt Revascularization: A Report From the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes)</title>
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<series><title level="j" type="main">Journal of the American College of Cardiology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angioplasty</term>
<term>Bypass</term>
<term>Cardiology</term>
<term>Cardiovascular disease</term>
<term>Circulatory system</term>
<term>Clinical trial</term>
<term>Comparative study</term>
<term>Coronary heart disease</term>
<term>Evolution</term>
<term>Female</term>
<term>Human</term>
<term>Instrumental dilatation</term>
<term>Instrumentation therapy</term>
<term>Male</term>
<term>Medicine</term>
<term>Patient</term>
<term>Prognosis</term>
<term>Revascularization</term>
<term>Sex</term>
<term>Type 2 diabetes</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Diabète de type 2</term>
<term>Cardiopathie coronaire</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Sexe</term>
<term>Mâle</term>
<term>Femelle</term>
<term>Etude comparative</term>
<term>Homme</term>
<term>Pronostic</term>
<term>Evolution</term>
<term>Malade</term>
<term>Médecine</term>
<term>Revascularisation</term>
<term>Essai clinique</term>
<term>Dérivation</term>
<term>Angioplastie</term>
<term>Dilatation instrumentale</term>
<term>Appareil circulatoire</term>
<term>Cardiologie</term>
<term>Traitement instrumental</term>
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<front><div type="abstract" xml:lang="en">Objectives This study evaluated differences in outcome among women and men enrolled in the BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) trial. Background Women and men with coronary artery disease have different clinical presentations and outcomes that might be due to differences in management. Methods We compared baseline variables, study interventions, and outcomes between women and men enrolled in the BARI 2D trial and randomized to aggressive medical therapy alone or aggressive medical therapy with prompt revascularization. Results At enrollment, women were more likely than men to have angina (67% vs. 58%, p < 0.01) despite less disease on angiography (Myocardial Jeopardy Index 41 ± 24 vs. 46 ± 24, p < 0.01; number of significant lesions 2.3 ± 1.7 vs. 2.8 ± 1.8, p < 0.01). Over 5 years, no sex differences were observed in BARI 2D study outcomes after adjustment for difference in baseline variables (death/myocardial infarction/cerebrovascular accident: hazard ratio: 1.11, 99% confidence interval [CI]: 0.85 to 1.44). However, women reported more angina than men (adjusted odds ratio: 1.51, 99% CI: 1.21 to 1.89, p < 0.0001) and had lower scores for the Duke Activity Status Index (adjusted beta coefficient: -1.58, 99% CI: -2.84 to -0.32, p < 0.01). Conclusions There were no sex differences in death, myocardial infarction, or cerebrovascular accident among patients enrolled in the BARI 2D trial. However, compared with men, women had more symptoms and less anatomic disease at baseline, with persistence of higher angina rates and lower DASI scores after 5 years of medical therapy with or without prompt revascularization. (Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes [BAR1 2D]; NCT00006305).</div>
</front>
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<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Tamis Holland, Jacqueline E" sort="Tamis Holland, Jacqueline E" uniqKey="Tamis Holland J" first="Jacqueline E." last="Tamis-Holland">Jacqueline E. Tamis-Holland</name>
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<name sortKey="Jacobs, Alice K" sort="Jacobs, Alice K" uniqKey="Jacobs A" first="Alice K." last="Jacobs">Alice K. Jacobs</name>
<name sortKey="Jiang Lu" sort="Jiang Lu" uniqKey="Jiang Lu" last="Jiang Lu">JIANG LU</name>
<name sortKey="Korytkowski, Mary" sort="Korytkowski, Mary" uniqKey="Korytkowski M" first="Mary" last="Korytkowski">Mary Korytkowski</name>
<name sortKey="Magee, Michelle" sort="Magee, Michelle" uniqKey="Magee M" first="Michelle" last="Magee">Michelle Magee</name>
<name sortKey="Rogers, William J" sort="Rogers, William J" uniqKey="Rogers W" first="William J." last="Rogers">William J. Rogers</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Lopes, Neuza" sort="Lopes, Neuza" uniqKey="Lopes N" first="Neuza" last="Lopes">Neuza Lopes</name>
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<country name="Canada"><noRegion><name sortKey="Mighton, Lisa" sort="Mighton, Lisa" uniqKey="Mighton L" first="Lisa" last="Mighton">Lisa Mighton</name>
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Sex Differences in Presentation and Outcome Among Patients With Type 2 Diabetes and Coronary Artery Disease Treated With Contemporary Medical Therapy With or Without Prompt Revascularization: A Report From the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes)

Sex Differences in Presentation and Outcome Among Patients With Type 2 Diabetes and Coronary Artery Disease Treated With Contemporary Medical Therapy With or Without Prompt Revascularization: A Report From the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes)

Source :

Descripteurs français

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Abstract

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